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DOI | 10.1016/J.IMBIO.2008.11.016 | ||||
Año | 2009 | ||||
Tipo | artículo de investigación |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
Recombinant replicons of Semliki Forest virus (SFV) can be used to induce high-level, transient expression of heterologous proteins in vivo. We constructed infectious but replication-deficient SFV particles carrying recombinant RNA encoding the Brucella abortus translation initiation factor 3 (IF3). The recombinant SFV particles (SFV-IF3 particles) were then evaluated for their ability to induce immune responses and to protect BALB/c mice against a challenge with B. abortus 2308 following vaccination. Animals inoculated with SFV-IF3 developed IF3-specific IgM antibodies at day 14 post-immunization. In vitro stimulation of splenocytes from vaccinated mice with either recombinant IF3 (rIF3) or crude Brucella protein extracts resulted in a T-cell proliferative response and induction of interferon gamma secretion, but not interleukin-4. In addition, mice immunized with SFV-IF3 exhibited a significant level of resistance against challenge with the virulent B. abortus strain 2308 (P<0.01). These findings indicate that an SFV-based vector carrying RNA encoding Brucella IF3 has potential for use as a vaccine to induce protection against B. abortus infections. (C) 2008 Elsevier GmbH. All rights reserved.
Ord. | Autor | Género | Institución - País |
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1 | Cabrera, Alex | Hombre |
Universidad de Concepción - Chile
Faculty of Biological Sciences - Chile |
2 | SAEZ-POBLETE, DARWIN RODRIGO | Hombre |
Universidad de Concepción - Chile
Faculty of Biological Sciences - Chile |
3 | Céspedes, Sandra | Mujer |
Universidad de Concepción - Chile
Faculty of Biological Sciences - Chile |
4 | Andrews, Edilia | Mujer |
Universidad de Concepción - Chile
Faculty of Biological Sciences - Chile |
5 | ONATE-CONTRERAS, ANGEL ALEJANDRO | Hombre |
Universidad de Concepción - Chile
Faculty of Biological Sciences - Chile |
Fuente |
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Comisión Nacional de Investigación Científica y Tecnológica |
Comisión Nacional de Investigación CientÃfica y Tecnológica |
Anillo del Programa Bicentenario en Ciencia y Biotecnologia (CONICYT), Santiago, Chile. |
Agradecimiento |
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This work was supported by the Grant "Anillo del Programa Bicentenario en Ciencia y Biotecnologia" ACT 08-2006 (CONICYT), Santiago, Chile. |
This work was supported by the Grant “Anillo del Programa Bicentenario en Ciencia y Biotecnología” ACT 08-2006 (CONICYT), Santiago, Chile. |