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DOI | 10.1002/JCP.27843 | ||||
Año | 2019 | ||||
Tipo | revisión |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
The prevalence of diabetes mellitus is growing rapidly worldwide. This metabolic disorder affects many physiological pathways and is a key underlying cause of a multitude of debilitating complications. There is, therefore, a critical need for effective diabetes management. Although many synthetic therapeutic glucose-lowering agents have been developed to control glucose homeostasis, they may have unfavorable side effects or limited efficacy. Herbal-based hypoglycemic agents present an adjunct treatment option to mitigate insulin resistance, improve glycemic control and reduce the required dose of standard antidiabetic medications. Saffron (Crocus sativus L.), whilst widely used as a food additive, is a natural product with insulin-sensitizing and hypoglycemic effects. Saffron contains several bioactive beta carotenes, which exert their pharmacological effects in various tissues without any obvious side effects. In this study, we discuss how saffron and its major components exert their hypoglycemic effects by induction of insulin sensitivity, improving insulin signaling and preventing beta-cell failure, all mechanisms combining to achieve better glycemic control.
Ord. | Autor | Género | Institución - País |
---|---|---|---|
1 | Yaribeygi, Habib | Hombre |
Shahid Beheshti Univ Med Sci - Iran
Shahid Beheshti University of Medical Sciences - Iran |
2 | Zare, Vahid | Hombre |
Baqiyatallah Univ Med Sci - Iran
Baqiyatallah University of Medical Sciences - Iran |
3 | Butler, Alexandra E. | Mujer |
Qatar Biomed Res Inst - Catar
Qatar Biomedical Research Institute - Catar |
4 | Barreto, George | Hombre |
Pontificia Univ Javeriana - Colombia
Universidad Autónoma de Chile - Chile Pontificia Universidad Javeriana - Colombia |
5 | Sahebkar, Amirhossein | - |
Mashhad Univ Med Sci - Iran
Mashhad University of Medical Sciences - Iran Neurojenic Inflammation Research Center - Iran |