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DOI | 10.1038/S41467-019-08501-W | ||||
Año | 2019 | ||||
Tipo | artículo de investigación |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
Inter-organelle signalling has essential roles in cell physiology encompassing cell metabolism, aging and temporal adaptation to external and internal perturbations. How such signalling coordinates different organelle functions within adaptive responses remains unknown. Membrane traffic is a fundamental process in which membrane fluxes need to be sensed for the adjustment of cellular requirements and homeostasis. Studying endoplasmic reticulum-to-Golgi trafficking, we found that Golgi-based, KDEL receptor-dependent signalling promotes lysosome repositioning to the perinuclear area, involving a complex process intertwined to autophagy, lipid-droplet turnover and Golgi-mediated secretion that engages the microtubule motor protein dynein-LRB1 and the autophagy cargo receptor p62/SQSTM1. This process, here named 'traffic-induced degradation response for secretion' (TIDeRS) discloses a cellular mechanism by which nutrient and membrane sensing machineries cooperate to sustain Golgi-dependent protein secretion.
Ord. | Autor | Género | Institución - País |
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1 | Tapia, Diego | Hombre |
Universidad San Sebastián - Chile
Universidad Nacional Andrés Bello - Chile Pontificia Universidad Católica de Chile - Chile |
2 | Jimenez, Tomas | Hombre |
Universidad San Sebastián - Chile
Universidad Nacional Andrés Bello - Chile Pontificia Universidad Católica de Chile - Chile |
3 | Zamora, Constanza | Mujer |
Universidad San Sebastián - Chile
Universidad Nacional Andrés Bello - Chile Pontificia Universidad Católica de Chile - Chile |
4 | Espinoza, Javier | Hombre |
Universidad Nacional Andrés Bello - Chile
Pontificia Universidad Católica de Chile - Chile |
5 | Rizzo, Riccardo | Hombre |
CNR - Italia
Istituto Di Biochimica Delle Proteine, Naples - Italia |
6 | Gonzalez-Cardenas, Alexis | Hombre |
Universidad Austral de Chile - Chile
|
7 | Fuentes, Danitza | - |
Pontificia Universidad Católica de Chile - Chile
|
8 | Hernandez, Sergio | Hombre |
Universidad San Sebastián - Chile
|
9 | Cavieres, Viviana A. | Mujer |
Universidad San Sebastián - Chile
Universidad Austral de Chile - Chile |
10 | Soza, Andrea | Mujer |
Universidad San Sebastián - Chile
Pontificia Universidad Católica de Chile - Chile |
11 | Guzman, Fanny | Mujer |
Fraunhofer Chile Res - Chile
Pontificia Universidad Católica de Valparaíso - Chile Fraunhofer Chile Research Foundation - Chile |
12 | ARRIAGADA-INOSTROZA, GLORIA LORETTO | Mujer |
Universidad Nacional Andrés Bello - Chile
Pontificia Universidad Católica de Chile - Chile |
13 | Yuseff, Maria-Isabel | Mujer |
Pontificia Universidad Católica de Chile - Chile
|
14 | Mardones, Gonzalo A. | Hombre |
Universidad San Sebastián - Chile
Universidad Austral de Chile - Chile |
15 | BURGOS-HITSCHFELD, PATRICIA VERONICA | Mujer |
Universidad San Sebastián - Chile
Pontificia Universidad Católica de Chile - Chile |
16 | Luini, Alberto | Hombre |
CNR - Italia
Istituto Di Biochimica Delle Proteine, Naples - Italia |
17 | GONZALEZ-DE LA ROSA, LUIS ALFONSO | Hombre |
Universidad San Sebastián - Chile
Pontificia Universidad Católica de Chile - Chile Fundación Ciencia y Vida - Chile |
18 | CANCINO-CANCINO, JORGE ORLANDO | Hombre |
Universidad San Sebastián - Chile
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Fuente |
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FONDECYT |
CONICYT |
UNAB |
Fondo Nacional de Desarrollo Científico y Tecnológico |
Comisión Nacional de Investigación Científica y Tecnológica |
Universidad Andrés Bello |
Comisión Nacional de Investigación CientÃfica y Tecnológica |
Fondo Nacional de Desarrollo CientÃfico y Tecnológico |
Universidad Andrés Bello |
FIRC Fellowship |
Fondazione Italiana per la Ricerca sul Cancro |
Agradecimiento |
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We would like to thank all colleagues at the Centro de Biologia Celular y Biomedicina (CEBICEM, Chile) and the Istituto de Biochimica delle Proteine (IBP, Italy) who kindly provided reagents and technical support, Dr. A. Peden (Department of Biomedical Science, University of Sheffield, Western Bank Sheffield, UK) for hGH-FM-GFP-expressing HeLa cells. J.C. was supported by FONDECYT No. 1150986 and UNAB DI-646-15R, G.A. by FONDECYT No. 1130852, M.I.Y. by FONDECYT 1141182, G.A.M. by FONDECYT No. 1161252, P.V.B. by FONDECYT No. 1171649, R.R. by FIRC Fellowship 15111, A.G. by FONDECYT No. 1181907 and CONICYT Basal Programme No. AFB-170005. V.A.C. was supported by CONICYT fellowship 21151194. |
We would like to thank all colleagues at the Centro de Biología Celular y Biomedicina (CEBICEM, Chile) and the Istituto de Biochimica delle Proteine (IBP, Italy) who kindly provided reagents and technical support, Dr. A. Peden (Department of Biomedical Science, University of Sheffield, Western Bank Sheffield, UK) for hGH-FM-GFP-expressing HeLa cells. J.C. was supported by FONDECYT No. 1150986 and UNAB DI-646–15R, G.A. by FONDECYT No. 1130852, M.I.Y. by FONDECYT 1141182, G.A.M. by FONDECYT No. 1161252, P.V.B. by FONDECYT No. 1171649, R.R. by FIRC Fellowship 15111, A.G. by FONDECYT No. 1181907 and CONICYT Basal Programme No. AFB-170005. V.A.C. was supported by CONICYT fellowship 21151194. |