Muestra métricas de impacto externas asociadas a la publicación. Para mayor detalle:
Indexado |
|
||||
DOI | 10.1155/2018/7278036 | ||||
Año | 2018 | ||||
Tipo | artículo de investigación |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
Copper and nickel nanoparticles (Cu-NPs and Ni-NPs, respectively) are used in a variety of industrial applications, such as semiconductors, catalysts, sensors, and antimicrobial agents. Although studies on its potential genotoxicity already exist, few of them report in vivo data. In the present study we have used the wing-spot assay in Drosophila melanogaster to determine the genotoxic activity of Cu-NPs and Ni-NPs, and these data have been compared with those obtained with their microparticle forms (MPs). Additionally, a complete physical characterization of NPs using transmission electronic microscopy (TEM), dynamic light scattering (DLS), and laser Doppler velocimetry (LDV) techniques was also performed. Results obtained with Cu-NPs and Cu-MPs indicate that both failed to induce an increase in the frequency of mutant spots formation in the wings of the adults, suggesting a lack of genotoxicity in somatic cells of D. melanogaster. However, when Ni-NPs and Ni-MPs were evaluated, a significant increase of small single spots and total mutant spots was observed only for Ni-NPs (P<0.05) at the highest dose assessed. Thus, the genotoxicity of Ni-NPs seem to be related to their nanoscale size, because no genotoxic effects have been reported with their microparticles and ions. This study is the first assessing the in vivo genotoxic potential of Cu-NPs and Ni-NPs in the Drosophila model.
Ord. | Autor | Género | Institución - País |
---|---|---|---|
1 | Carmona, Erico | Hombre |
Universidad Católica de Temuco - Chile
|
2 | Garcia-Rodriguez, Alba | Mujer |
UNIV AUTONOMA BARCELONA - España
Universitat Autònoma de Barcelona - España |
3 | Marcos, Ricard | Hombre |
UNIV AUTONOMA BARCELONA - España
Inst Salud Carlos III - España Universitat Autònoma de Barcelona - España CIBER Epidemiología Y Salud Pública - España Instituto de Salud Carlos III - España |
Fuente |
---|
Fondo Nacional de Desarrollo Científico y Tecnológico |
Comisión Nacional de Investigación Científica y Tecnológica |
FONDECYT-CONICYT |
Universidad Católica de Córdoba |
Dirección General de Investigación Científica y Técnica |
Dirección General de Investigación CientÃfica y Técnica |
Direccion General de Investigacion y Postgrado, Universidad Catolica de Temuco |
Universidad Católica de Córdoba |
Agradecimiento |
---|
The authors acknowledge the financial support given by FONDECYT-CONICYT, Project 11110181; Direccion General de Investigacion y Postgrado, Universidad Catolica de Temuco, DGIP UCT CD 2010-01 project, and MECESUP UCT 0804 project. The authors are grateful to M.J. Rivadeneira and M.M. Carmona for revising the English version of the manuscript. |
The authors acknowledge the financial support given by FONDECYT-CONICYT, Project 11110181; Dirección General de Investigacíon y Postgrado, Universidad Católica de Temuco, DGIP UCT CD 2010-01 project, and MECESUP UCT 0804 project. The authors are grateful to M.J. Rivadeneira and M.M. Carmona for revising the English version of the manuscript. |