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DOI | 10.1016/J.MOLSTRUC.2017.06.014 | ||||
Año | 2017 | ||||
Tipo | artículo de investigación |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
The reaction of CrCl(3)6H(2)O with the ligand bis(3,5-dimethylpyrazol-1-yl)methane (L) yielded the cationic complex [(Cr(L)(H2O)(2)Cl-2](+), which crystallized as the chloride trihydrate [(Cr(L)(H2O)(2)Cl-2]Cl.3H(2)O. The chromium complex was characterized by elemental analysis, electrical conductivity, Infrared and Ultraviolet/Visible spectroscopy. The crystal structure determination using single-crystal X-ray diffraction showed a chromium center in a distorted octahedral coordination sphere. In the crystal, the packing was directed by O-H...(O,Cl) hydrogen bonds and weak C-H...O interactions to build a monoclinic P2(1)/c supramolecular structure. The complex showed excellent properties as an initiator for the ring opening polymerization of epsilon-caprolactone (CL) under solvent-free conditions. The obtained polymer showed high crystallinity (89.9%) and a decomposition temperature above 475 degrees C. In addition, the new complex was evaluated against epimastigotes from Trypanosoma cruzi (T. cruzi) strains. The results indicated that this complex has a high activity against this parasite with a minimum inhibitory concentration 50 (MIC50) of 1.08 mu g/mL. Interestingly, this compound showed little effect on erythrocytes, indicating that it is not cytotoxic. These results provide interesting contributions to the design of metal complexes by using simple and accessible ligands with activity against T. cruzi and with potential applications in the polymerization of CL. (C) 2017 Elsevier B.V. All rights reserved.
Ord. | Autor | Género | Institución - País |
---|---|---|---|
1 | Hurtado, John J. | Hombre |
Universidad de Los Andes, Chile - Colombia
Universidad de Los Andes, Colombia - Colombia |
2 | Ibarra, Laura | Mujer |
Universidad de Los Andes, Chile - Colombia
Universidad de Los Andes, Colombia - Colombia |
3 | Yepes, David | Hombre |
Universidad de Los Andes, Chile - Colombia
Universidad de Los Andes, Colombia - Colombia |
4 | Garcia-Huertas, Paola | Mujer |
UNIV ANTIOQUIA - Colombia
Universidad de Antioquia - Colombia |
5 | Macias, Mario A. | Hombre |
Universidad de Los Andes, Chile - Colombia
Universidad de Los Andes, Colombia - Colombia |
6 | Triana-Chavez, Omar | Hombre |
UNIV ANTIOQUIA - Colombia
Universidad de Antioquia - Colombia |
7 | NAGLES-VIDAL, EDGAR ORLANDO | Hombre |
Univ Ibague - Colombia
Universidad de Ibagué - Colombia |
8 | Suescun, Leopoldo | Hombre |
UNIV REPUBLICA - Uruguay
Universidad de la República Facultad de Química - Uruguay Universidad La República - Uruguay Universidad de la República - Uruguay |
9 | Munoz-Castro, Alvaro | Hombre |
Universidad Autónoma de Chile - Chile
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Fuente |
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FONDECYT |
Fondo Nacional de Desarrollo Científico y Tecnológico |
Universidad de Antioquia |
Universidad de los Andes |
CSIC |
Agencia Nacional de Investigación e Innovación |
Consejo Superior de Investigaciones Científicas |
Fondo Nacional de Desarrollo CientÃfico, Tecnológico y de Innovación Tecnológica |
School of Science of the Universidad de los Andes |
ANII |
Agencia Nacional de Investigación e Innovación |
Comisión Sectorial de Investigación CientÃfica |
Department of Chemistry of the Universidad de los Andes |
Ibague University |
Facultad de Quimica |
Universidad de Antioquia-UdeA |
Agradecimiento |
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Thanks to the Department of Chemistry and the School of Science of the Universidad de los Andes for the financial support. O. Triana acknowledges the Universidad de Antioquia-UdeA. E. Nagles acknowledges the Ibague University project 16-416-INT. M. Macias wishes to thank ANII (EQC_2012_07), CSIC and Facultad de Quimica for the funds to purchase the diffractometer. MAM also thanks ANII for his post-doctoral contract (PD_NAC_2014_1_102409). A. Munoz-Castro thanks FONDECYT 1140359 for financial support. We thank the reviewers and editor for their useful comments. |
Thanks to the Department of Chemistry and the School of Science of the Universidad de los Andes for the financial support. O. Triana acknowledges the Universidad de Antioquia-UdeA. E. Nagles acknowledges the Ibague University project 16-416-INT. M. Macías wishes to thank ANII (EQC_2012_07), CSIC and Facultad de Química for the funds to purchase the diffractometer. MAM also thanks ANII for his post-doctoral contract (PD_NAC_2014_1_102409). A. Muñoz-Castro thanks FONDECYT 1140359 for financial support. We thank the reviewers and editor for their useful comments. |