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Indexado |
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DOI | 10.1186/S12920-015-0121-1 | ||||
Año | 2015 | ||||
Tipo | artículo de investigación |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
Conclusions: For the first time, we show the power of combining RNA taxonomic profiling and host gene expression signatures for microbial identification. Our approach not only identifies microbes from metagenomic data, but also adds support to these inferences by determining if the host is mounting a response against specific infectious agents. In particular, we show that M. catarrhalis is abundant in asthma patients but not in controls, and that its presence is associated with a specific host gene expression signature.
Ord. | Autor | Género | Institución - País |
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1 | Castro-Nallar, Eduardo | Hombre |
GEORGE WASHINGTON UNIV - Estados Unidos
Universidad Nacional Andrés Bello - Chile The George Washington University - Estados Unidos |
2 | Shen, Ying | - |
BOSTON UNIV - Estados Unidos
Boston University School of Medicine - Estados Unidos Boston University Chobanian & Avedisian School of Medicine - Estados Unidos |
3 | Freishtat, Robert J. | Hombre |
Childrens Natl Med Ctr - Estados Unidos
Childrens National Health System - Estados Unidos |
4 | Perez-Losada, M. | Hombre |
GEORGE WASHINGTON UNIV - Estados Unidos
Childrens Natl Med Ctr - Estados Unidos Univ Porto - Portugal The George Washington University - Estados Unidos Childrens National Health System - Estados Unidos Universidade do Porto, Centro de Investigação em Biodiversidade e Recursos Genéticos - Portugal CIBIO - Centro de Investigação em Biodiversidade e Recursos Genéticos - Portugal |
5 | Manimaran, Solaiappan | - |
BOSTON UNIV - Estados Unidos
Boston University School of Medicine - Estados Unidos Boston University Chobanian & Avedisian School of Medicine - Estados Unidos |
6 | Liu, Gang | - |
BOSTON UNIV - Estados Unidos
Boston University School of Medicine - Estados Unidos Boston University Chobanian & Avedisian School of Medicine - Estados Unidos |
7 | Johnson, W. Evan | - |
BOSTON UNIV - Estados Unidos
Boston University School of Medicine - Estados Unidos Boston University Chobanian & Avedisian School of Medicine - Estados Unidos |
8 | Crandall, Keith A. | Hombre |
GEORGE WASHINGTON UNIV - Estados Unidos
The George Washington University - Estados Unidos |
Fuente |
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Comisión Nacional de Investigación Científica y Tecnológica |
National Heart, Lung, and Blood Institute |
National Institute on Minority Health and Health Disparities |
K12 Career Development Program |
GW's Computational Biology Institute |
CONICYT + PAI/CONCURSO NACIONAL APOYO AL RETORNO DE INVESTIGADORES/AS DESDE EL EXTRANJERO, CONVOCATORIA + FOLIO |
Agradecimiento |
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ECN would like to thank GW's Computational Biology Institute for funding and GW's Colonial One High-Performance Computing facility for facilitating infrastructure for analyses. ECN was funded by "CONICYT + PAI/CONCURSO NACIONAL APOYO AL RETORNO DE INVESTIGADORES/AS DESDE EL EXTRANJERO, CONVOCATORIA 2014 + FOLIO 82140008". MP-L was funded by a K12 Career Development Program 5 K12 HL119994 award. |
ECN would like to thank GW’s Computational Biology Institute for funding and GW’s Colonial One High-Performance Computing facility for facilitating infrastructure for analyses. ECN was funded by "CONICYT + PAI/CONCURSO NACIONAL APOYO AL RETORNO DE INVESTIGADORES/AS DESDE EL EXTRANJERO, CONVOCATORIA 2014 + FOLIO 82140008". MP-L was funded by a K12 Career Development Program 5 K12 HL119994 award. |