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Dual Transcriptomic Profiling of Host and Microbiota during Health and Disease in Pediatric Asthma
| Indexado |
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| DOI | 10.1371/JOURNAL.PONE.0131819 | ||||
| Año | 2015 | ||||
| Tipo | artículo de investigación |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
Abstract
Our study showed significant differences in the metabolism of microbiomes from asthmatic and non-asthmatic children for up to 25% of the functional properties tested. Enrichment analysis of 499 differentially expressed host genes for inflammatory and immune responses revealed 43 upstream regulators differentially activated in asthma. Microbial adhesion (virulence) and Proteobacteria abundance were significantly associated with variation in the expression of the upstream regulator IL1A; suggesting that microbiome characteristics modulate host inflammatory and immune systems during asthma.
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| 1 | Perez-Losada, M. | Hombre |
GEORGE WASHINGTON UNIV - Estados Unidos
Childrens Natl Med Ctr - Estados Unidos Univ Porto - Portugal The George Washington University - Estados Unidos Childrens National Health System - Estados Unidos Universidade do Porto, Centro de Investigação em Biodiversidade e Recursos Genéticos - Portugal CIBIO - Centro de Investigação em Biodiversidade e Recursos Genéticos - Portugal |
| 2 | Castro-Nallar, Eduardo | Hombre |
GEORGE WASHINGTON UNIV - Estados Unidos
Universidad Nacional Andrés Bello - Chile The George Washington University - Estados Unidos |
| 3 | Bendall, Matthew L. | Hombre |
GEORGE WASHINGTON UNIV - Estados Unidos
The George Washington University - Estados Unidos |
| 4 | Freishtat, Robert J. | Hombre |
Childrens National Health System - Estados Unidos
|
| 5 | Crandall, Keith A. | Hombre |
GEORGE WASHINGTON UNIV - Estados Unidos
The George Washington University - Estados Unidos |
| Fuente |
|---|
| National Science Foundation |
| National Heart, Lung, and Blood Institute |
| National Center for Advancing Translational Sciences |
| National Institute on Minority Health and Health Disparities |
| K12 Career Development Program |
| National Institute of Health to National Center for Advancing Translational Sciences |
| CONICYT + PAI/ Concurso nacional apoyo al retorno de investigadores/as desde el extranjero, convocatoria + folio |
| Agradecimiento |
|---|
| MP-L was funded in part by a K12 Career Development Program 5 K12 HL119994 award. EC-N was funded by "CONICYT + PAI/ Concurso nacional apoyo al retorno de investigadores/as desde el extranjero, convocatoria 2014 + folio 82140008". This study was supported by Award Number UL1TR000075 from the National Institute of Health to National Center for Advancing Translational Sciences. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Center for Advancing Translational Sciences or the National Institutes of Health. |
